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Importantly, top GO terms that related to the ECM structure, organization, and collagen fibril organization were depleted at p28 compared to p14, confirming the importance of AF lamellar and collagen organization in p14 regenerative mice (Figures 7C and S9), and providing an external validation that disrupted collagen crosslinking is likely to be a key factor limiting regenerative healing in p14-BAPN animals
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