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Although many epidemiological and genetic studies have been conducted in clinical practice, the specific molecular mechanism by which ferroptosis mediates the increased risk of DM has not been extensively studied in humans, and more studies have been carried out in animal and cell models
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PEROXIREDOXIN–THIOREDOXIN REDOX CYCLE Peroxiredoxins constitute a family of thiol-specific peroxidases that rely on thioredoxins (Trxs) as the hydrogen donor for the reduction of H 2 O 2 and lipid hydroperoxides (Chae et al., 1999)
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