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Such diseases often arise from impaired vascular function, leading to severe complications such as myocardial infarction and cerebrovascular accidents ( Current senolytic agents are primarily employed in cancer therapies, such as doxorubicin, trametinib, and cell cycle-targeting drugs like palbociclib ( Although studies have shown that FOXO4-DRI can block the binding of P53 to FOXO4, thereby promoting the apoptosis of senescent cells, the effect of FOXO4-DRI is not limited to alleviating the aging of certain organs

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OTA and its metabolites, along with their categorization, are listed in Table 3