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From a chemical standpoint, common features of BET inhibitors include a planar heteroaromatic core that fills the KAc pocket, substituents that tune physicochemical properties and selectivity, and the feasibility of late-stage functionalization (e.g., amidation, N-alkylation, and cross-coupling reactions), enabling rapid generation of analogue libraries while preserving the key pharmacophore [194,195]

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Most people find they want far less of it anyway as the appetite effect dampens cravings across the board

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