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Under low iron conditions or upon disruption of mitochondrial Fe-S cluster biogenesis, the Fra2/ Grx3/ Grx4 signaling pathway is proposed to interpret and transmit a signal to the iron-responsive transcription factor Aft1 (and presumably its paralog Aft2), allowing Aft1 to accumulate in the nucleus and activate the iron regulon [114–116], which encodes proteins involved in iron uptake, transport, and storage [129–131]
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