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These exosomes promote a significant increase in the expression of integrin α νβ -5 and tissue inhibitor of matrix metalloproteinase-1 ( TIMP-1 ) along with a concomitant decrease in plasminogen activator inhibitor-1 ( PAI-1 ) and matrix metalloproteinase-7 ( MMP-7 ) expression in HepG2 cells
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Preclinical studies report that Dihexa increases dendritic spine density and functional synapses in cultured hippocampal neurons at very low concentrations, and improves spatial learning in rats with scopolamine-induced deficits and in aged animals, including after oral administration
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