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The gradual death of neurons, resulting in a loss of brain function, such as cognition, age-related dysregulation of biochemical pathways, and alterations of gene expression, is poorly understood and current therapies are still ineffective

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It is designed as a competitive antagonist that mimics the p53-binding domain of the FOXO4 (Forkhead box O4) transcription factor, thereby selectively disrupting the FOXO4-p53 interaction