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Hepatic Microsomal Ethanol-Oxidizing System (MEOS): CYP2E1 ๐งฌ Chronic alcohol consumption doesn't just increase toleranceโit rewires liver metabolism. The CYP2E1 enzyme, part of the MEOS pathway, becomes upregulated and plays a key role
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Therefore, these observations indicate that alterations on mitochondrial CB1 receptors in the brain could represent a novel therapeutical tool, as well as a possible mechanism underlying the behavioral alterations elicited by cannabinoid consumption
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