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22 On the other hand, certain biomolecules, such as nesfatin-1, can reduce ASIC1a protein levels through the MAPK/ERK and NF-κB pathways, thereby inhibiting acidosis-induced oxidative stress, inflammation and apoptosis in chondrocytes, which has a beneficial effect on alleviating arthritis symptoms
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doi: 10.3389/fcell.2022.933370
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