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Additionally, trypsin activates the protease-2 receptor, inducing the secretion of IL-8, a neutrophil chemotactic factor involved in the inflammatory response (Reference Kandulski, Wex and MönkemĂŒller45,Reference Yoshida, Katada and Handa46)
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This regulatory relationship is inversely validated at the molecular level: the GPX4 inhibitor RSL3 potently induces ferroptosis by binding to its active site, serving as a reliable experimental tool for studying ferroptosis in AD and directly establishing a causal link between GPX4 inhibition and AD pathology (191)
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