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ISA-induced S phase arrest is found to be associated with reduced levels of cyclin A, cyclin B1 and CDK2 (Rasul et al., 2013b)
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Accordingly, the SLC1A2 gene that encodes the astrocytic excitatory amino acid transporter 2 (EAAT2, responsible for majority of glutamate re-uptake in the brain) is a susceptibility locus to BD (Fiorentino et al., 2014)
The 500 mg dosage per capsule provides an optimal amount of ALC to support energy production at the cellular level
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