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In contrast, immunomodulatory pathways play an essential role in the neuroprotective effect of Vit D and N-3 PUFAs (EPA and DHA), as evidenced by their ability to reduce the levels of the inflammatory cytokines IL-6 and TNF-α and increase the levels of the anti-inflammatory cytokine IL-10, thereby attenuating the neuroinflammation caused by MSG in the current study 103 , which has been widely reported in previous animal studies 103,104,105,106 , and demonstrates an additional synergetic neuroprotective effect of their combined supplementation