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In addition to directly stimulating ROS production through Nox4, mitochondria, and/or microsomes, TGF-β may increase ROS/RNS levels by suppressing the expression of several antioxidant enzymes including glutaredoxin, catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx) [110–112], and by decreasing the concentration of glutathione, the most abundant intracellular free thiol and an important antioxidant (the effect of TGF-β on GSH metabolism is detailed in the following section)
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Used under medical supervision, they can ease symptoms like fatigue, pain, and cognitive fog
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