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The phosphorylation level of tau protein at the Thr231 and Ser262 sites was not significantly different between the OA and OA + naltrindole groups (Figures 3E–G), while the total tau has not changed (Figure 3H)
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In the axonal loss, which is considered to be the main cause of permanent clinical disability in MS, key elements are inflammation, mitochondrial alteration, upregulation of sodium channels and glutamate excitotoxicity
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