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3-PH can obtain an amino group from glutamate and form 3-phosphoserine (3-PS) through phosphoserine transaminase (PSAT) followed by dephosphorylation through serine phosphatase (PSPH) to finally produce serine (Figure 1)

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Given the semi-pragmatic nature of the trial, MCI and dementia classifications were based on PCP diagnoses and not on neuropsychological evaluation, which takes over an hour, and is neither routine nor practical for detecting cognitive impairment in primary care