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Mitochondrial Glutathione: Recent Insights and Role in Disease
These cupric ions interact with the zinc fingers of NPL4 and lock the conformational switch of NPL4/p97 complex essential for the unfolding activity of the p97, hence, inhibits the function of p97 (Pan et al., 2021)
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Additional limitations include potential simplifications in synthesizing complex mechanisms of toxin-induced carcinogenesis
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