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To test this, scientists used an exercise-challenge model in both rodents and humans to induce inflammation and evaluate whether the ability of L-carnitine tartrate to downregulate ACE2 expression could translate to an attenuation of SARS-CoV-2 infectivity in an in vitro human lung epithelial cell-based system 5

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also, the accumulated glutamic acid can directly act as a signaling molecule to activate channels such as NMDA receptors, intensifying intracellular calcium overload and oxidative stress (Table 3)