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The research ethics committee of the School of Medicine, Tohoku University, approved this study, which was conducted in accordance with the ethical guidelines of the 1975 Declaration of Helsinki
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This diet is a modification of the AIN-93M semi-purified diet, comprising 73% carbohydrate, 13% protein, and 4% fat, with sufficient essential vitamins and minerals, except Se, which was eliminated at 0.1 ppm, a figure approximately comparable to the Recommended Dietary Allowance for adult humans as reported by Kasaikina et al
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