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Disclosing a metabolic signature of cisplatin resistance in MDA-MB-231 triple-negative breast cancer cells by NMR metabolomics | Cancer Cell International | Springer Nature Link

While clinical outcomes were mixed, likely due to pharmacokinetic limitations as exemplified by the failure of the Phase III MICONOS trial to meet its primary neurological endpoints, and the Phase III IONIA trial for cardiomyopathy, the molecular rationale can now be reinterpreted [95-97]

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The response is dependent on temperature conditions