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In addition to GSH, 6 studies also assessed plasma GSSG (N = 3) (Jones et al., 2002, Kretzschmar et al., 1991, Yang et al., 1995), GSH/GSSG (N = 1) (Paolisso et al., 1998) and/or tGSH (N = 3) (Andriollo-Sanchez et al., 2005, Kretzschmar et al., 1991, Nuttall et al., 1998) levels

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Compared to controls, ALS patient lower motor neurons exhibit significantly lower levels of these epigenetic markers, suggesting an association between TDP-43 and DNA methylation, while changes in glial cell methylation are minimal and primarily affect lower motor neurons (151)