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Remarkably, the locomotor response to a combination of morphine and M6G was not greater than that observed after morphine alone [178], and while pre-treatment with morphine sensitized the locomotor response to M6G, pre-treatment with M6G did not sensitize the response to morphine [180]

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It has been demonstrated that the mitochondrial respiratory chain and NADPH oxidase (NOX) are the primary sources of endogenous ROS in AML cells, whereas the accumulation of ROS in LSCs is further aggravated by the dysregulation of antioxidant response factors (GLRX, GPX, PRDX, and GSR)