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They originate from OPCs (oligodendrocyte progenitor cells), which, when in an advanced stage of maturation, migrate to the periphery of the axonal fibers and, through a combination of epigenetic, translational and environmental cues interconnected through a SOX10 mediation, differentiate into full myelinating oligodendrocytes (89)
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In other words, CHB patients with a functional cure may still harbor a low level of HBV protein expression
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