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When you don’t have enough B12 in your body, these two major systems will suffer and you will end up with symptoms like: Macrocytic anemia Fatigue or low-energy Mood changes like depression or anxiety Sleep disturbances like insomnia Cognitive & memory problems Difficulty with concentration Non-specific GI issues Nerve problems And more Given the wide range of symptoms associated with a B12 deficiency, it can sometimes be hard to pinpoint this problem, especially when you consider the co-existence of functional folate deficiency which often goes hand in hand with b12 deficiency