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It reduces sperm quality through a variety of mechanisms, such as sex hormone deficiency, DNA damage, oxidative stress, apoptosis, spermatogenesis disturbance, and zinc finger protein deficiency

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Additionally, SGLT2 inhibitors have been shown to be beneficial in the prevention of AKI in two different randomized, placebo-controlled trials: Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME) and Dapagliflozin Effect on Cardiovascular Events-Thrombolysis in Myocardial Infarction 58 (DECLARE-TIMI 58) (137, 138)

and has been shown to boost athletic performance