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VEGFA released in the TME increases the expression of PD1 and other inhibitory checkpoints involved in CD8 + T cell exhaustion, which can be countered by anti-angiogenic agents that target VEGFA–VEGFR
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The expression level of neurexin-1 increased with age, neurexin-3 remained stable, and neurexin-2 was higher than neurexin-1 and neurexin-3 at the early stage, but intermediate between neurexin-1 and neurexin-3 at the later stage [66]
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