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This is in accordance with previous studies showing that abundant ROS production is one of the characteristics of RAS activation (31, 33)
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Consistently, CAT s showed stage-specific expression—distinct isoforms predominating at different phases—whereas many GPX s (with higher affinity for H 2 O 2 and frequently implicated in signaling) were induced by mannitol and further upregulated at 48 h of in vitro culture
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